| Bioactivity | [Au(L4)(CyJohnPhos)]SbF6 is a gold containing complex. [Au(L4)(CyJohnPhos)]SbF6 inhibits cyclooxygenase-1/2 (COX-1/2), inhibits the proliferation (IC50 is 0.98 μM) and induces apoptosis in colon cancer cell Caco2-/TC7. [Au(L4)(CyJohnPhos)]SbF6 is also an inhibitor for thioredoxin reductase (TrxR), thereby exhibits antioxidant activity by modulating ROS levels[1]. |
| Formula | C44H56AuF6NO4PSSb |
| Molar Mass | 1158.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Saez J, et al., Gold(I) Complexes Based on Nonsteroidal Anti-Inflammatory Derivatives as Multi-Target Drugs against Colon Cancer. Inorg Chem. 2024 Oct 21;63(42):19769-19782. |
[Au(L4)(CyJohnPhos)]SbF6
CAS: F: C44H56AuF6NO4PSSb W: 1158.68
SbF6 is a gold containing complex. SbF6 inhibits cyclooxygenase-1/2 (COX-1/2), inhibits the proliferation (IC50 is 0.98
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